e-mail: bernd.klosterhalfen()web.de
Prof. Dr. med. B. Klosterhalfen studierte von 1982 bis 1988 Humanmedizin an der RWTH-Aachen. Es folgten die Promotion 1989, sowie AIP und Assistenzarztjahre in der Pathologie und Chirurgie in den Jahren 1989 bis 1993. Im Jahr 1998 erfolgte die Anerkennung als Facharzt für Pathologie sowie die Erlangung der Venia legendi für das Fach Pathologie and anatomische Pathologie.
Anerkennung der fakultativen Weiterbildung Molekularpathologie im Jahr 2002.
Bis 3/2003 Tätigkeit als Oberarzt in Aachen, seit 4/2003 in leitender Stellung am Institut für Pathologie in Düren. Seit 2/2007 Chefarzt für Pathologie am Krankenhaus Düren sowie geschäftsführender Arzt der dort ansässigen Praxisgemeinschaft.
Zwischen 1993 und 2003 erfolgte eine breit gefächerte Ausbildung in der allgemeinen und speziellen Pathologie mit Schwerpunkten in der Mamma- und Uropathologie, der Gastroenteropathologie sowie der Pathologie des Bewegungsapparates. Auch in Düren werden diese Schwerpunkte und die Molekularpathologie im besonderen Maße von Prof. Klosterhalfen vertreten.
Wissenschaftlichen Schwerpunkte bildeten vor allem funktionelle Tierstudien auf dem Gebiet der Intensivmedizin unter besonderer Berücksichtigung der Sepsis und der Ischämie, in vitro Studien zur Pathogenese verschiedener Tumoren, sowie die Biomaterialforschung.
Die Biomaterialforschung ist heute ein wesentlicher Schwerpunkt der wissenschaftlichen Aktivitäten am Institut für Pathologie in Düren. Ermöglicht wird dies durch enge Kooperationen mit verschiedenen Partnern aus Industrie und Hochschule (siehe auch Biomaterialforschung), insbesondere der Firmen BMP GmbH, Bayer AG, Ethicon GmbH, Braun Melsungen, FEG Textiltechnik (u.a.) und der RWTH Aachen. Im Rahmen der Kooperation mit der Fa. BMP GmbH in Aachen leitet Prof. Dr. med. B. Klosterhalfen das einzige in Deutschland zertifizierte und akkreditierte pathologische Labor für die Testung und Zulassung von Biowerkstoffen, Implantaten und Medizinprodukten.
Prof. Dr. med. B. Klosterhalfen ist seit 1986 Autor und Coautor von über 200 Publikationen und über 300 Vorträgen, Gewinner zahlreicher Preise auf dem Gebiet der Intensivmedizin und Biomaterialforschung sowie Inhaber verschiedenster Patente. Er ist Mitglied verschiedener Gesellschaften auf dem Gebieten der Pathologie, Intensivmedizin und Biomaterialforschung, Reviewer zahlreicher nationaler und internationaler Fachzeitschriften sowie Editor des Journals Expert Reviews of Medical Devices.
Publikationsliste (Auswahl):
Orginalien
1. Vogel, PKlosterhalfen, B. [The surgical anatomy of the rectal and anal blood vessels]. Langenbecks Arch Chir 373, 264-9 (1988)
2. Klosterhalfen, B, Vogel, P, Rixen, H, and Mittermayer, C. Topography of the inferior rectal artery: a possible cause of chronic, primary anal fissure. Dis Colon Rectum 32, 43-52 (1989)
3. Klosterhalfen, B, Offner, F, Topf, N, Vogel, P, and Mittermayer, C. Sclerosis of the internal anal sphincter--a process of aging. Dis Colon Rectum 33, 606-9 (1990)
4. Klinge, U, Klosterhalfen, B, Tons, C, and Schumpelick, V. [A bleeding complication as a consequence of bolus lysis after resuscitation]. Dtsch Med Wochenschr 116, 1293 (1991)
5. Klosterhalfen, B, Horstmann-Jungemann, K, Vogel, P, et al. Hemodynamic variables and plasma levels of PGI2, TXA2 and IL-6 in a porcine model of recurrent endotoxemia. Circ Shock 35, 237-44 (1991)
6. Klosterhalfen, B, Offner, F, Vogel, P, and Kirkpatrick, CJ. Anatomic nature and surgical significance of anal sinus and anal intramuscular glands. Dis Colon Rectum 34, 156-60 (1991)
7. Klosterhalfen, B, Offner, FA, Kirkpatrick, CJ, and Mittermayer, C. Pathology of multiple organ failure. Contrib Nephrol 93, 71-5 (1991)
8. Offner, FA, Ott, G, Povey, S, et al. Characterization of the new bladder cancer cell line HOK-1: expression of transitional, squamous and glandular differentiation patterns. Int J Cancer 49, 122-8 (1991)
9. Riesener, KP, Dreuw, B, de Jager, JC, Klosterhalfen, B, and Schumpelick, V. [Jejunal diverticulosis--a rare cause of gastrointestinal hemorrhage]. Leber Magen Darm 21, 175-8 (1991)
10. Simon, HB, Mertens, H, Lohmer, P, et al. [Effects of a defined infusion of 10% HAES 200/0.5 in the early phase of a septic syndrome on hemodynamic parameters]. Infusionstherapie 18, 301-5 (1991)
11. Treutner, KH, Winkeltau, G, Tittel, A, Klosterhalfen, B, and Schumpelick, V. [Mesenteric panniculitis]. Chirurg 62, 62-4 (1991)
12. Vogel, P, Klosterhalfen, B, Kirkpatrick, CJ, and Schone, S. Fibrinogen degradation product-D, fibrinogen, and serum change polymorphonuclear granulocyte activity--possibly important post-trauma? J Trauma 31, 87-92 (1991)
13. Klosterhalfen, B, Horstmann-Jungemann, K, Vogel, P, et al. Time course of various inflammatory mediators during recurrent endotoxemia. Biochem Pharmacol 43, 2103-9 (1992)
14. Offner, FA, Wirtz, HC, Schiefer, J, et al. Interaction of human malignant melanoma (ST-ML-12) tumor spheroids with endothelial cell monolayers. Damage to endothelium by oxygen-derived free radicals. Am J Pathol 141, 601-10 (1992)
15. Truong, S, Klosterhalfen, B, Arlt, G, Muckter, H, and Schumpelick, V. [Endoscopic therapy of benign anastomotic stenoses in the area of the colon and rectum by electro-incision and balloon dilatation]. Langenbecks Arch Chir 377, 271-5 (1992)
16. Winkeltau, G, Winkeltau, GU, Klosterhalfen, B, et al. [Differential surgical therapy in diffuse peritonitis]. Chirurg 63, 1035-40 (1992)
17. Hauptmann, S, Zwadlo-Klarwasser, G, Jansen, M, Klosterhalfen, B, and Kirkpatrick, CJ. Macrophages and multicellular tumor spheroids in co-culture: a three-dimensional model to study tumor-host interactions. Evidence for macrophage-mediated tumor cell proliferation and migration. Am J Pathol 143, 1406-15 (1993)
18. Muller-Leisse, C, Klosterhalfen, B, Hauptmann, S, et al. Computed tomography and histologic results in the early stages of endotoxin-injured pig lungs as a model for adult respiratory distress syndrome. Invest Radiol 28, 39-45 (1993)
19. Offner, FA, Bigalke, I, Schiefer, J, et al. Interaction of human malignant melanoma tumor spheroids with endothelium and reconstituted basement membrane: modulation by RGDS. Int J Cancer 54, 506-12 (1993)
20. Peters, KM, Klosterhalfen, B, Zwadlo-Klarwasser, G, et al. [Lymphocyte defects in chronic osteomyelitis. A prospective study]. Unfallchirurg 96, 29-33 (1993)
21. Tons, C, Klosterhalfen, B, Klinge, U, et al. [Septic shock and multiple organ failure in surgical intensive care. An animal experiment model on the analysis of pulmonary and intestinal dysfunction]. Langenbecks Arch Chir 378, 217-32 (1993)
22. Hauptmann, S, Zwadlo-Klarwasser, G, Hartung, P, et al. Association of different macrophage phenotypes with infiltrating and non-infiltrating areas of tumor-host interface in colorectal carcinoma. Pathol Res Pract 190, 159-67 (1994)
23. Hauptmann, S, Klosterhalfen, B, Weis, J, Mittermayer, C, and Kirkpatrick, CJ. Skeletal muscle oedema and muscle fibre necrosis during septic shock. Observations with a porcine septic shock model. Virchows Arch 424, 653-9 (1994)
24. Hauptmann, S, Bernauer, J, Zwadlo-Klarwasser, G, Klosterhalfen, B, and Kirkpatrick, CJ. Differential adherence of the human monocyte subsets 27E10 and RM3/1 to cytokine- or glucocorticoid-treated endothelial cells. Pathobiology 62, 262-8 (1994)
25. Hauptmann, S, Zardi, L, Siri, A, et al. Extracellular matrix proteins in colorectal carcinomas. Expression of tenascin and fibronectin isoforms. Lab Invest 73, 172-82 (1995)
26. Hauptmann, S, Denkert, C, Lohrke, H, et al. Integrin expression on colorectal tumor cells growing as monolayers, as multicellular tumor spheroids, or in nude mice. Int J Cancer 61, 819-25 (1995)
27. Hauptmann, S, Klosterhalfen, B, Weis, J, et al. Morphology of cardiac muscle in septic shock. Observations with a porcine septic shock model. Virchows Arch 426, 487-91 (1995)
28. Klein, HM, Lensing, R, Klosterhalfen, B, Tons, C, and Gunther, RW. Diagnostic imaging of mesenteric infarction. Radiology 197, 79-82 (1995)
29. Tacke, J, Adam, G, Sliwka, U, Klosterhalfen, B, and Schondube, F. [Diagnosis of an infected thrombus of the inferior vena cava with ultrasound and computerized tomography]. Radiologe 35, 521-3 (1995)
30. Kirkpatrick, CJ, Bittinger, F, Klein, CL, Hauptmann, S, and Klosterhalfen, B. The role of the microcirculation in multiple organ dysfunction syndrome (MODS): a review and perspective. Virchows Arch 427, 461-76 (1996)
31. Klein, HM, Klosterhalfen, B, Kinzel, S, et al. CT and MRI of experimentally induced mesenteric ischemia in a porcine model. J Comput Assist Tomogr 20, 254-61 (1996)
32. Klinge, U, Conze, J, Klosterhalfen, B, et al. [Changes in abdominal wall mechanics after mesh implantation. Experimental changes in mesh stability]. Langenbecks Arch Chir 381, 323-32 (1996)
33. Klosterhalfen, B, Tons, C, Hauptmann, S, et al. Influence of heat shock protein 70 and metallothionein induction by zinc-bis-(DL-hydrogenaspartate) on the release of inflammatory mediators in a porcine model of recurrent endotoxemia. Biochem Pharmacol 52, 1201-10 (1996)
34. Klosterhalfen, B, Peters, KM, Tons, C, et al. Local and systemic inflammatory mediator release in patients with acute and chronic posttraumatic osteomyelitis. J Trauma 40, 372-8 (1996)
35. Offner, FA, Schiefer, J, Wirtz, HC, et al. Tumour-cell-endothelial interactions: free radicals are mediators of melanoma-induced endothelial cell damage. Virchows Arch 428, 99-106 (1996)
36. Peters, KM, Koberg, K, Rosendahl, T, et al. Macrophage reactions in septic arthritis. Arch Orthop Trauma Surg 115, 347-50 (1996)
37. Tons, C, Klosterhalfen, B, and Schumpelick, V. [Monitoring critically ill intensive care patients by semi-invasive COLD (Cardiac-Output-Liver-Diseases) monitoring instead of pulmonary artery catheterization]. Langenbecks Arch Chir Suppl Kongressbd 113, 349-52 (1996)
38. Willis, S, Conze, J, Muller, S, Klosterhalfen, B, and Schumpelick, V. [Progressive pneumoperitoneum in treatment of inguinal and scar hernias. Results of animal experiments and clinical applications]. Langenbecks Arch Chir 381, 132-7 (1996)
39. Bertram, P, Treutner, KH, Klosterhalfen, B, et al. [Artificial pressure increase in subcutaneous abscess with evidence of general systemic reaction]. Langenbecks Arch Chir 382, 291-4 (1997)
40. Bhardwaj, RS, Henze, U, Klein, B, et al. Monocyte-biomaterial interaction inducing phenotypic dynamics of monocytes: a possible role of monocyte subsets in biocompatibility. J Mater Sci Mater Med 8, 737-42 (1997)
41. Henze, U, Lennartz, A, Hafemann, B, et al. The influence of the C1-inhibitor BERINERT and the protein-free haemodialysate ACTIHAEMYL20% on the evolution of the depth of scald burns in a porcine model. Burns 23, 473-7 (1997)
42. Klinge, U, Prescher, A, Klosterhalfen, B, and Schumpelick, V. [Development and pathophysiology of abdominal wall defects]. Chirurg 68, 293-303 (1997)
43. Klosterhalfen, B, Hauptmann, S, Tietze, L, et al. The influence of heat shock protein 70 induction on hemodynamic variables in a porcine model of recurrent endotoxemia. Shock 7, 358-63 (1997)
44. Klosterhalfen, B, Hauptmann, S, Offner, FA, et al. Induction of heat shock protein 70 by zinc-bis-(DL-hydrogenaspartate) reduces cytokine liberation, apoptosis, and mortality rate in a rat model of LD100 endotoxemia. Shock 7, 254-62 (1997)
45. Klosterhalfen, B, Klinge, U, Henze, U, et al. [Morphologic correlation of functional abdominal wall mechanics after mesh implantation]. Langenbecks Arch Chir 382, 87-94 (1997)
46. Nachtkamp, J, Klosterhalfen, B, Pott, S, Magin, MN, and Paar, O. [Ligamentization as an explanation for the stability of periosteal flap repair in the replacement of the fibular ligament system]. Chirurg 68, 1146-9 (1997)
47. Schumpelick, V, Arlt, G, Schlachetzki, A, and Klosterhalfen, B. [Chronic inguinal pain after transperitoneal mesh implantation. Case report of net shrinkage]. Chirurg 68, 1297-300 (1997)
48. Schurmann, K, Vorwerk, D, Bucker, A, et al. Perigraft inflammation due to Dacron-covered stent-grafts in sheep iliac arteries: correlation of MR imaging and histopathologic findings. Radiology 204, 757-63 (1997)
49. Schurmann, K, Vorwerk, D, Uppenkamp, R, et al. Iliac arteries: plain and heparin-coated Dacron-covered stent-grafts compared with noncovered metal stents--an experimental study. Radiology 203, 55-63 (1997)
50. Tons, C, Klosterhalfen, B, Klein, HM, et al. Induction of heat shock protein 70 (HSP70) by zinc bis (DL-hydrogen aspartate) reduces ischemic small-bowel tissue damage in rats. Langenbecks Arch Chir 382, 43-8 (1997)
51. Hauptmann, S, Gebauer-Hartung, P, Leclere, A, et al. Induction of apoptosis in the centre of multicellular tumour spheroids of colorectal adenocarcinomas--involvement of CD95 pathway and differentiation. Apoptosis 3, 267-79 (1998)
52. Khorram-Sefat, R, Goldmann, C, Radke, A, et al. The therapeutic effect of C1-inhibitor on gut-derived bacterial translocation after thermal injury. Shock 9, 101-8 (1998)
53. Klinge, U, Klosterhalfen, B, Muller, M, Ottinger, AP, and Schumpelick, V. Shrinking of polypropylene mesh in vivo: an experimental study in dogs. Eur J Surg 164, 965-9 (1998)
54. Klinge, U, Klosterhalfen, B, Conze, J, et al. Modified mesh for hernia repair that is adapted to the physiology of the abdominal wall. Eur J Surg 164, 951-60 (1998)
55. Klosterhalfen, B, Klinge, U, and Schumpelick, V. Functional and morphological evaluation of different polypropylene-mesh modifications for abdominal wall repair. Biomaterials 19, 2235-46 (1998)
56. Klosterhalfen, BBhardwaj, RS. Septic shock. Gen Pharmacol 31, 25-32 (1998)
57. Neuerburg, J, Adam, G, Bucker, A, et al. [A new MR-(and CT-) compatible bone biopsy system: first clinical results]. Rofo 169, 515-20 (1998)
58. Schurmann, K, Vorwerk, D, Uppenkamp, R, et al. Determination of stent stenosis: an in vivo experimental comparison of intravascular ultrasound and angiography with histology. Cardiovasc Intervent Radiol 21, 189-98 (1998)
59. Tacke, J, Vorwerk, D, Klosterhalfen, B, and Gunther, RW. [Experimental model of early chronic pelvic vein thrombosis with occlusion spirals and thrombin]. Rofo 169, 645-8 (1998)
60. Tietze, L, Elbrecht, A, Schauerte, C, et al. Modulation of pro- and antifibrinolytic properties of human peritoneal mesothelial cells by transforming growth factor beta1 (TGF-beta1), tumor necrosis factor alpha (TNF-alpha) and interleukin 1beta (IL-1beta). Thromb Haemost 79, 362-70 (1998)
61. Klinge, U, Zheng, H, Si, ZY, et al. Synthesis of type I and III collagen, expression of fibronectin and matrix metalloproteinases-1 and -13 in hernial sac of patients with inguinal hernia. Int J Surg Investig 1, 219-27 (1999)
62. Klinge, U, Zheng, H, Si, Z, et al. Expression of the extracellular matrix proteins collagen I, collagen III and fibronectin and matrix metalloproteinase-1 and -13 in the skin of patients with inguinal hernia. Eur Surg Res 31, 480-90 (1999)
63. Klinge, U, Klosterhalfen, B, Muller, M, and Schumpelick, V. Foreign body reaction to meshes used for the repair of abdominal wall hernias. Eur J Surg 165, 665-73 (1999)
64. Klinge, U, Klosterhalfen, B, Muller, M, et al. Influence of polyglactin-coating on functional and morphological parameters of polypropylene-mesh modifications for abdominal wall repair. Biomaterials 20, 613-23 (1999)
65. Schiffer, R, Klein, B, Klosterhalfen, B, and Zwadlo-Klarwasser, G. The contact of human macrophages with extracellular matrix proteins selectively induces expression of proinflammatory cytokines. Pathobiology 67, 233-5 (1999)
66. Schumpelick, V, Klinge, U, Welty, G, and Klosterhalfen, B. [Meshes within the abdominal wall]. Chirurg 70, 876-87 (1999)
67. Schumpelick, V, Klosterhalfen, B, Muller, M, and Klinge, U. [Minimized polypropylene mesh for preperitoneal net plasty (PNP) of incisional hernias]. Chirurg 70, 422-30 (1999)
68. Tacke, J, Vorwerk, D, Bucker, A, et al. Experimental treatment of early chronic iliac vein thrombosis with a modified hydrodynamic thrombectomy catheter: preliminary animal experience. J Vasc Interv Radiol 10, 57-63 (1999)
69. Tietze, L, Borntraeger, J, Klosterhalfen, B, et al. Expression and function of beta(1) and beta(3) integrins of human mesothelial cells in vitro. Exp Mol Pathol 66, 131-9 (1999)
70. Hoer, J, Roegels, A, Prescher, A, et al. [Preserving autonomic nerves in rectal surgery. Results of surgical preparation on human cadavers with fixed pelvic sections]. Chirurg 71, 1222-9 (2000)
71. Klinge, U, Si, ZY, Zheng, H, et al. Abnormal collagen I to III distribution in the skin of patients with incisional hernia. Eur Surg Res 32, 43-8 (2000)
72. Klosterhalfen, B, Klinge, U, Tietze, L, et al. Expression of heat shock protein 70 (HSP70) at the interface of polymer-implants in vivo. J Mater Sci Mater Med 11, 175-81 (2000)
73. Klosterhalfen, B, Klinge, U, Hermanns, B, and Schumpelick, V. [Pathology of traditional surgical nets for hernia repair after long-term implantation in humans]. Chirurg 71, 43-51 (2000)
74. Lopez-Cotarelo, C, Sellhaus, B, Baba, HA, et al. Expression of heat shock proteins 72/73 in human peritoneal mesothelial cells in vivo and in vitro. Nephron 85, 148-55 (2000)
75. Merz, U, Kellinghaus, M, Hausler, M, et al. Effects of prolonged partial liquid ventilation, high frequency ventilation and conventional ventilation on gas exchange and lung pathology in newborn surfactant-depleted piglets. Shock 13, 472-7 (2000)
76. Merz, U, Kellinghaus, M, Hausler, M, et al. Partial liquid ventilation with surfactant: effects on gas exchange and lung pathology in surfactant-depleted piglets. Intensive Care Med 26, 109-16 (2000)
77. Radke, A, Mottaghy, K, Goldmann, C, et al. C1 inhibitor prevents capillary leakage after thermal trauma. Crit Care Med 28, 3224-32 (2000)
78. Schurmann, K, Haage, P, Meyer, J, et al. Comparison of two stent-grafts with different porosity: in vivo studies in a sheep model. J Vasc Interv Radiol 11, 493-502 (2000)
79. Tietze, L, Gunther, K, Horbe, A, et al. Benign metastasizing leiomyoma: a cytogenetically balanced but clonal disease. Hum Pathol 31, 126-8 (2000)
80. Willis, S, Klosterhalfen, B, Titkova, S, et al. Effect of artificial valves on intestinal adaptation in the short-bowel syndrome: an integrated study of morphological and functional changes in rats. Eur Surg Res 32, 111-9 (2000)
81. Bhardwaj, RS, Eblenkamp, M, Berndt, T, Tietze, L, and Klosterhalfen, B. Role of HSP70i in regulation of biomaterial-induced activation of human monocytes-derived macrophages in culture. J Mater Sci Mater Med 12, 97-106 (2001)
82. Haage, P, Tacke, J, Bovelander, J, et al. Prototype percutaneous thrombolytic device: preclinical testing in subacute inferior vena caval thrombosis in a pig model. Radiology 220, 135-41 (2001)
83. Hermann, S, Sturm, I, Mrozek, A, et al. Bax expression in benign and malignant thyroid tumours: dysregulation of wild-type P53 is associated with a high Bax and P21 expression in thyroid carcinoma. Int J Cancer 92, 805-11 (2001)
84. Klein, B, Schiffer, R, Hafemann, B, Klosterhalfen, B, and Zwadlo-Klarwasser, G. Inflammatory response to a porcine membrane composed of fibrous collagen and elastin as dermal substitute. J Mater Sci Mater Med 12, 419-24 (2001)
85. Klinge, U, Schumpelick, V, and Klosterhalfen, B. Functional assessment and tissue response of short- and long-term absorbable surgical meshes. Biomaterials 22, 1415-24 (2001)
86. Klinge, U, Si, ZY, Zheng, H, et al. Collagen I/III and matrix metalloproteinases (MMP) 1 and 13 in the fascia of patients with incisional hernias. J Invest Surg 14, 47-54 (2001)
87. Merz, U, Klosterhalfen, B, Kellinghaus, M, et al. Effects of single and multiple doses of perfluorocarbon in comparison with continuous partial liquid ventilation on gas exchange and lung pathology in newborn surfactant-depleted pigs. Crit Care Med 29, 645-51 (2001)
88. Qing, M, Vazquez-Jimenez, JF, Klosterhalfen, B, et al. Influence of temperature during cardiopulmonary bypass on leukocyte activation, cytokine balance, and post-operative organ damage. Shock 15, 372-7 (2001)
89. Stumpf, M, Cao, W, Klinge, U, et al. Increased distribution of collagen type III and reduced expression of matrix metalloproteinase 1 in patients with diverticular disease. Int J Colorectal Dis 16, 271-5 (2001)
90. Unger, JK, Janssen, VR, Kashefi, A, et al. Enhancing filtration rates by the use of blood flow around the capillaries of plasmafilters: an in vitro study. Int J Artif Organs 24, 821-31 (2001)
91. Unger, JK, Horn, NA, Kashefi, A, et al. The influence of hypoalbuminemia on maximal flow rates and transmembrane pressure during plasmapheresis--an in vitro study. Blood Purif 19, 408-16 (2001)
92. Vazquez-Jimenez, JF, Qing, M, Hermanns, B, et al. Moderate hypothermia during cardiopulmonary bypass reduces myocardial cell damage and myocardial cell death related to cardiac surgery. J Am Coll Cardiol 38, 1216-23 (2001)
93. Welty, G, Klinge, U, Klosterhalfen, B, Kasperk, R, and Schumpelick, V. Functional impairment and complaints following incisional hernia repair with different polypropylene meshes. Hernia 5, 142-7 (2001)
94. Zwadlo-Klarwasser, G, Gorlitz, K, Hafemann, B, Klee, D, and Klosterhalfen, B. The chorioallantoic membrane of the chick embryo as a simple model for the study of the angiogenic and inflammatory response to biomaterials. J Mater Sci Mater Med 12, 195-9 (2001)
95. Denkert, C, Kobel, M, Pest, S, et al. Expression of cyclooxygenase 2 is an independent prognostic factor in human ovarian carcinoma. Am J Pathol 160, 893-903 (2002)
96. Junge, K, Klinge, U, Klosterhalfen, B, et al. Influence of mesh materials on collagen deposition in a rat model. J Invest Surg 15, 319-28 (2002)
97. Junge, K, Klinge, U, Rosch, R, Klosterhalfen, B, and Schumpelick, V. Functional and morphologic properties of a modified mesh for inguinal hernia repair. World J Surg 26, 1472-80 (2002)
98. Junge, K, Klinge, U, Klosterhalfen, B, et al. Review of wound healing with reference to an unrepairable abdominal hernia. Eur J Surg 168, 67-73 (2002)
99. Kisielinski, K, Willis, S, Prescher, A, Klosterhalfen, B, and Schumpelick, V. A simple new method to calculate small intestine absorptive surface in the rat. Clin Exp Med 2, 131-5 (2002)
100. Klinge, U, Junge, K, Spellerberg, B, et al. Do multifilament alloplastic meshes increase the infection rate? Analysis of the polymeric surface, the bacteria adherence, and the in vivo consequences in a rat model. J Biomed Mater Res 63, 765-71 (2002)
101. Klinge, U, Klosterhalfen, B, Ottinger, AP, Junge, K, and Schumpelick, V. PVDF as a new polymer for the construction of surgical meshes. Biomaterials 23, 3487-93 (2002)
102. Klinge, U, Klosterhalfen, B, Birkenhauer, V, et al. Impact of polymer pore size on the interface scar formation in a rat model. J Surg Res 103, 208-14 (2002)
103. Klinge, U, Junge, K, Stumpf, M, Ap, AP, and Klosterhalfen, B. Functional and morphological evaluation of a low-weight, monofilament polypropylene mesh for hernia repair. J Biomed Mater Res 63, 129-36 (2002)
104. Klosterhalfen, B, Junge, K, Hermanns, B, and Klinge, U. Influence of implantation interval on the long-term biocompatibility of surgical mesh. Br J Surg 89, 1043-8 (2002)
105. Merz, U, Klosterhalfen, B, Hausler, M, et al. Partial liquid ventilation reduces release of leukotriene B4 and interleukin-6 in bronchoalveolar lavage in surfactant-depleted newborn pigs. Pediatr Res 51, 183-9 (2002)
106. Mittermayer, C, Eblenkamp, M, Richter, HA, et al. [Pathology of implants]. Kongressbd Dtsch Ges Chir Kongr 119, 491-7 (2002)
107. Qing, M, Vazquez-Jimenez, JF, Schumacher, K, et al. Moderate hypothermia during cardiopulmonary bypass increases intramyocardial synthesis of heat shock protein 72. J Thorac Cardiovasc Surg 124, 724-31 (2002)
108. Quester, R, Klosterhalfen, B, Stutzer, H, Schroder, R, and Klug, N. Polyester meshes and adhesive materials in the brain: comparative research in rats to optimize surgical strategy. J Neurosurg 96, 760-9 (2002)
109. Rosch, R, Junge, K, Tons, C, et al. [Weakly malignant leiomyosarcoma of the inferior vena cava. A case report]. Chirurg 73, 950-3 (2002)
110. Rosch, R, Klinge, U, Si, Z, et al. A role for the collagen I/III and MMP-1/-13 genes in primary inguinal hernia? BMC Med Genet 3, 2 (2002)
111. Schachtrupp, A, Toens, C, Hoer, J, et al. A 24-h pneumoperitoneum leads to multiple organ impairment in a porcine model. J Surg Res 106, 37-45 (2002)
112. Si, Z, Bhardwaj, R, Rosch, R, et al. Impaired balance of type I and type III procollagen mRNA in cultured fibroblasts of patients with incisional hernia. Surgery 131, 324-31 (2002)
113. Stumpf, M, Cao, W, Klinge, U, et al. Collagen distribution and expression of matrix metalloproteinases 1 and 13 in patients with anastomotic leakage after large-bowel surgery. Langenbecks Arch Surg 386, 502-6 (2002)
114. Toens, C, Schachtrupp, A, Hoer, J, et al. A porcine model of the abdominal compartment syndrome. Shock 18, 316-21 (2002)
115. Willis, S, Kisielinski, K, Klosterhalfen, B, and Schumpelick, V. Morphological and functional adaptation of the small intestine after colectomy and ileal pouch-anal anastomosis in rats. Int J Colorectal Dis 17, 85-91 (2002)
116. Zheng, H, Si, Z, Kasperk, R, et al. Recurrent inguinal hernia: disease of the collagen matrix? World J Surg 26, 401-8 (2002)
117. Zimny, M, Klosterhalfen, B, Conze, J, et al. Uptake of cis-4-[18 F]fluoro-L-proline in scar formation: a marker of collagen synthesis? Nucl Med Commun 23, 695-8 (2002)
118. Daebritz, SH, Sachweh, JS, Hermanns, B, et al. Introduction of a flexible polymeric heart valve prosthesis with special design for mitral position. Circulation 108 Suppl 1, II134-9 (2003)
119. Fernandez, V, Peiper, C, Klosterhalfen, B, and Schumpelick, V. [Ileocecal invagination due to a benign small intestine tumor. A case report]. Chirurg 74, 856-9 (2003)
120. Junge, K, Rosch, R, Bialasinski, L, et al. Persistent extracellular matrix remodelling at the interface to polymers used for hernia repair. Eur Surg Res 35, 497-504 (2003)
121. Junge, K, Marx, A, Peiper, C, Klosterhalfen, B, and Schumpelick, V. Caecal-diverticulitis: a rare differential diagnosis for right-sided lower abdominal pain. Colorectal Dis 5, 241-5 (2003)
122. Quester, R, Hermanns, B, Klosterhalfen, B, Schroder, R, and Klug, N. Biocompatibility and healing process of polyester meshes in the brain: in vivo examination in rats. Biomaterials 24, 711-21 (2003)
123. Rosch, R, Junge, K, Quester, R, et al. Vypro II mesh in hernia repair: impact of polyglactin on long-term incorporation in rats. Eur Surg Res 35, 445-50 (2003)
124. Rosch, R, Junge, K, Schachtrupp, A, et al. Mesh implants in hernia repair. Inflammatory cell response in a rat model. Eur Surg Res 35, 161-6 (2003)
125. Schnoor, J, Bartz, S, Klosterhalfen, B, et al. A long-term porcine model for measurement of gastrointestinal motility. Lab Anim 37, 145-54 (2003)
126. Schwarz, ER, Kersting, PH, Reffelmann, T, et al. Cardioprotection by Carvedilol: antiapoptosis is independent of beta-adrenoceptor blockage in the rat heart. J Cardiovasc Pharmacol Ther 8, 207-15 (2003)
127. Siggelkow, W, Faridi, A, Spiritus, K, et al. Histological analysis of silicone breast implant capsules and correlation with capsular contracture. Biomaterials 24, 1101-9 (2003)
128. Stadlmann, S, Raffeiner, R, Amberger, A, et al. Disruption of the integrity of human peritoneal mesothelium by interleukin-1beta and tumor necrosis factor-alpha. Virchows Arch 443, 678-85 (2003)
129. Franke, RP, Reuter, P, Rohlke, W, et al. Interaction between a perfluorocarbon emulsion and radiographic contrast media. J Invasive Cardiol 16, 110-2 (2004)
130. Junge, K, Klinge, U, Rosch, R, et al. Decreased collagen type I/III ratio in patients with recurring hernia after implantation of alloplastic prostheses. Langenbecks Arch Surg 389, 17-22 (2004)
131. Krones, C, Klosterhalfen, B, Fackeldey, V, et al. Deleterious effect of zinc in a pig model of acute endotoxemia. J Invest Surg 17, 249-56 (2004)
132. Schurmann, K, Lahann, J, Niggemann, P, et al. Biologic response to polymer-coated stents: in vitro analysis and results in an iliac artery sheep model. Radiology 230, 151-62 (2004)
133. Siggelkow, W, Faridi, A, Klinge, U, Rath, W, and Klosterhalfen, B. Ki67, HSP70 and TUNEL for the specification of testing of silicone breast implants in vivo. J Mater Sci Mater Med 15, 1355-60 (2004)
134. Siggelkow, W, Klosterhalfen, B, Klinge, U, Rath, W, and Faridi, A. Analysis of local complications following explantation of silicone breast implants. Breast 13, 122-8 (2004)
135. Hermanns-Sachweh, B, Stemper, A, Klosterhalfen, B, et al. Light microscopic, immunohistochemical, and ultrastructural findings in congenital fibular aplasia or hypoplasia (FAH). Pediatr Dev Pathol 8, 474-82 (2005)
136. Hermanns-Sachweh, B, Senderek, J, Alfer, J, et al. Vascular changes in the periosteum of congenital pseudarthrosis of the tibia. Pathol Res Pract 201, 305-12 (2005)
137. Junge, K, Rosch, R, Krones, CJ, et al. Influence of polyglecaprone 25 (Monocryl) supplementation on the biocompatibility of a polypropylene mesh for hernia repair. Hernia 9, 212-7 (2005)
138. Junge, K, Rosch, R, Klinge, U, et al. Titanium coating of a polypropylene mesh for hernia repair: effect on biocompatibilty. Hernia 9, 115-9 (2005)
139. Junge, K, Rosch, R, Klinge, U, et al. Gentamicin supplementation of polyvinylidenfluoride mesh materials for infection prophylaxis. Biomaterials 26, 787-93 (2005)
140. Klosterhalfen, B, Junge, K, and Klinge, U. The lightweight and large porous mesh concept for hernia repair. Expert Rev Med Devices 2, 103-17 (2005)
141. Krones, CJ, Klosterhalfen, B, Anurov, M, et al. Missing effects of zinc in a porcine model of recurrent endotoxemia. BMC Surg 5, 22 (2005)
142. Krones, CJ, Klosterhalfen, B, Butz, N, et al. Effect of zinc pretreatment on pulmonary endothelial cells in vitro and pulmonary function in a porcine model of endotoxemia. J Surg Res 123, 251-6 (2005)
143. Matschke, K, Franke, RP, Mrowietz, C, et al. Myocardial oxygen tension during fatal right heart failure following perfluorocarbon and radiographic contrast agent interaction. Clin Hemorheol Microcirc 33, 57-62 (2005)
144. Staatz, G, Spuntrup, E, Klosterhalfen, B, et al. [High-resolution T1-weighted MR-lymphography of inguinal lymph nodes after interstitial application of Gadomer-17 in animal experiments]. Rofo 177, 968-74 (2005)
145. Stumpf, M, Cao, W, Klinge, U, et al. Reduced expression of collagen type I and increased expression of matrix metalloproteinases 1 in patients with Crohn's disease. J Invest Surg 18, 33-8 (2005)
146. Rosch, R, Lynen-Jansen, P, Junge, K, et al. Biomaterial-dependent MMP-2 expression in fibroblasts from patients with recurrent incisional hernias. Hernia 10, 125-30 (2006)
147. Muellenbach, RM, Kredel, M, Said, HM, et al. High-frequency oscillatory ventilation reduces lung inflammation: a large-animal 24-h model of respiratory distress. Intensive Care Med 33, 1423-33 (2007)
148. Schuster, D, Klosterhalfen, B, Fiedler, C, and Prescher, A. [Metastasis of medullary plasmocytoma as the cause of acute cholecystitis]. Dtsch Med Wochenschr 132, 612-5 (2007) |
